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dc.contributor.authorStrandvik, Birgitta
dc.contributor.authorQureshi, Abdul Rashid
dc.contributor.authorPainer, Johanna
dc.contributor.authorBackman-Johansson, Carolina
dc.contributor.authorEngvall, Martin
dc.contributor.authorFröbert, Ole
dc.contributor.authorKindberg, Jonas
dc.contributor.authorStenvinkel, Peter
dc.contributor.authorGiroud, Sylvain
dc.date.accessioned2023-06-15T07:58:31Z
dc.date.available2023-06-15T07:58:31Z
dc.date.created2023-06-14T11:01:19Z
dc.date.issued2023
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/11250/3071490
dc.description.abstractFactors for initiating hibernation are unknown, but the condition shares some metabolic similarities with consciousness/sleep, which has been associated with n-3 fatty acids in humans. We investigated plasma phospholipid fatty acid profiles during hibernation and summer in freeranging brown bears (Ursus arctos) and in captive garden dormice (Eliomys quercinus) contrasting in their hibernation patterns. The dormice received three different dietary fatty acid concentrations of linoleic acid (LA) (19%, 36% and 53%), with correspondingly decreased alphalinolenic acid (ALA) (32%, 17% and 1.4%). Saturated and monounsaturated fatty acids showed small differences between summer and hibernation in both species. The dormice diet influenced n-6 fatty acids and eicosapentaenoic acid (EPA) concentrations in plasma phospholipids. Consistent differences between summer and hibernation in bears and dormice were decreased ALA and EPA and marked increase of n-3 docosapentaenoic acid and a minor increase of docosahexaenoic acid in parallel with several hundred percent increase of the activity index of elongase ELOVL2 transforming C20-22 fatty acids. The highest LA supply was unexpectantly associated with the highest transformation of the n-3 fatty acids. Similar fatty acid patterns in two contrasting hibernating species indicates a link to the hibernation phenotype and requires further studies in relation to consciousness and metabolismen_US
dc.language.isoengen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleElevated plasma phospholipid n-3 docosapentaenoic acid concentrations during hibernationen_US
dc.title.alternativeElevated plasma phospholipid n-3 docosapentaenoic acid concentrations during hibernationen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2023 The Authorsen_US
dc.subject.nsiVDP::Zoologiske og botaniske fag: 480en_US
dc.subject.nsiVDP::Zoology and botany: 480en_US
dc.subject.nsiVDP::Zoologiske og botaniske fag: 480en_US
dc.subject.nsiVDP::Zoology and botany: 480en_US
dc.source.volume18en_US
dc.source.journalPLOS ONEen_US
dc.source.issue6en_US
dc.identifier.doi10.1371/journal.pone.0285782
dc.identifier.cristin2154380
dc.relation.projectAndre: Austria Science Funden_US
dc.relation.projectAndre: Westman Foundationen_US
dc.relation.projectAndre: ALFen_US
dc.relation.projectAndre: University of Veterinary Medicine Viennaen_US
dc.relation.projectAndre: Heart and Lung Foundationen_US
dc.relation.projectAndre: CIMEDen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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