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dc.contributor.authorBertolotti, Alicia C.
dc.contributor.authorLayer, Ryan M.
dc.contributor.authorGundappa, Manu Kumar
dc.contributor.authorGallagher, Michael D.
dc.contributor.authorPehlivanoglu, Ege
dc.contributor.authorNome, Torfinn
dc.contributor.authorRobledo, Diego
dc.contributor.authorKent, Matthew Peter
dc.contributor.authorRøsæg, Line Lieblein
dc.contributor.authorHolen, Matilde Mengkrog
dc.contributor.authorMulugeta, Teshome Dagne
dc.contributor.authorAshton, Thomas J.
dc.contributor.authorHindar, Kjetil
dc.contributor.authorSægrov, Harald
dc.contributor.authorFlorø-Larsen, Bjørn
dc.contributor.authorErkinaro, Jaakko
dc.contributor.authorPrimmer, Craig R.
dc.contributor.authorBernatchez, Louis
dc.contributor.authorMartin, Samuel A.M.
dc.contributor.authorJohnston, Ian A.
dc.contributor.authorSandve, Simen Rød
dc.contributor.authorLien, Sigbjørn
dc.contributor.authorMacqueen, Daniel J.
dc.description.abstractStructural variants (SVs) are a major source of genetic and phenotypic variation, but remain challenging to accurately type and are hence poorly characterized in most species. We present an approach for reliable SV discovery in non-model species using whole genome sequencing and report 15,483 high-confidence SVs in 492 Atlantic salmon (Salmo salar L.) sampled from a broad phylogeographic distribution. These SVs recover population genetic structure with high resolution, include an active DNA transposon, widely affect functional features, and overlap more duplicated genes retained from an ancestral salmonid autotetraploidization event than expected. Changes in SV allele frequency between wild and farmed fish indicate polygenic selection on behavioural traits during domestication, targeting brain-expressed synaptic networks linked to neurological disorders in humans. This study offers novel insights into the role of SVs in genome evolution and the genetic architecture of domestication traits, along with resources supporting reliable SV discovery in non-model species.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleThe structural variation landscape in 492 Atlantic salmon genomesen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© The Author(s) 2020en_US
dc.subject.nsiVDP::Klinisk veterinærmedisinske fag: 950en_US
dc.subject.nsiVDP::Clinical veterinary sciences: 950en_US
dc.subject.nsiVDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480en_US
dc.source.journalNature Communicationsen_US
dc.relation.projectNorges forskningsråd: 221734en_US

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