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dc.contributor.authorFröbert, Ole
dc.contributor.authorFröbert, Anne Mette
dc.contributor.authorKindberg, Jonas
dc.contributor.authorArnemo, Jon Martin
dc.contributor.authorOvergaard, Michael Toft
dc.date.accessioned2020-02-20T08:50:45Z
dc.date.available2020-02-20T08:50:45Z
dc.date.issued2019
dc.identifier.issn0954-6820
dc.identifier.urihttp://hdl.handle.net/11250/2642746
dc.description.abstractSedentary lifestyle accelerates biological ageing, is a major risk factor for developing metabolic syndrome and is associated with cardiovascular disease, diabetes mellitus, kidney failure, sarcopenia and osteoporosis. In contrast to the linear path to worsening health in humans with metabolic syndrome, brown bears have developed a circular metabolic plasticity enabling these animals to tolerate obesity and a ‘sedentary lifestyle’ during hibernation and exit the den metabolically healthy in spring. Bears are close to humans physiology wise, much closer than rodents, the preferred experimental animals in medical research, and may better serve as translational model to develop treatments for lifestyle-related diseases. In this review, aspects of brown bear hibernation survival strategies are outlined and conceivable experimental strategies to learn from bears are described.nb_NO
dc.language.isoengnb_NO
dc.subjectbrown bearnb_NO
dc.subjecthibernationnb_NO
dc.subjectmetabolic syn-dromenb_NO
dc.subjecttranslational researchnb_NO
dc.titleThe Brown bear as a translational model for sedentary lifestyle-related diseasesnb_NO
dc.typePeer reviewednb_NO
dc.typeJournal article
dc.description.versionacceptedVersionnb_NO
dc.rights.holder©2019 The Association for the Publication of the Journal of Internal Medicinenb_NO
dc.subject.nsiVDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480nb_NO
dc.source.journalJournal of Internal Medicinenb_NO
dc.identifier.doi10.1111/joim.12983
dc.identifier.cristin1739008


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