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dc.contributor.authorJørgensen, Peter Godsk
dc.contributor.authorEvans, Alina
dc.contributor.authorKindberg, Jonas
dc.contributor.authorOlsen, Lisbeth Høier
dc.contributor.authorGalatius, Søren
dc.contributor.authorFröbert, Ole
dc.coverage.spatialScandinavia, Skandinavia, Skandinaviennb_NO
dc.description.abstractDuring six months of annual hibernation, the brown bear undergoes unique physiological changes to adapt to decreased metabolic rate. We compared cardiac structural and functional measures of hibernating and active bears using comprehensive echocardiography. We performed echocardiography on 13 subadult free-ranging, anaesthetised Scandinavian brown bears (Ursus arctos) during late hibernation and in early summer. Mean heart rate was 26 beats per minute (standard deviation (SD): 8) during hibernation vs 71 (SD: 14) during active state. All left ventricular (LV) systolic and diastolic measures were decreased during hibernation: mean ejection fraction: 44.2% (SD: 6.0) active state vs 34.0 (SD: 8.1) hibernation, P = 0.001; global longitudinal strain: −11.2% (SD: 2.0) vs −8.8 (SD: 3.3), P = 0.03; global longitudinal strain rate: −0.82 (SD: 0.15) vs −0.41 (SD: 0.18), P < 0.001; septal e’: 9.8 cm/s (SD: 1.8) vs 5.2 (SD: 2.7), P < 0.001. In general, measures of total myocardial motion (ejection fraction and global longitudinal strain) were decreased to a lesser extent than measures of myocardial velocities. in the hibernating brown bear, cardiac adaptation included decreased functional measures, primarily measures of myocardial velocities, but was not associated with cardiac atrophy. Understanding the mechanisms of these adaptations could provide pathophysiological insight of human pathological conditions such as heart failure.nb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleCardiac adaptation in hibernating, free-ranging Scandinavian Brown Bears (Ursus arctosnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.rights.holder© The Author(s) 2020nb_NO
dc.source.journalScientific Reportsnb_NO
dc.relation.projectAndre: Swedish Association for Hunting and Wildlife Managementnb_NO
dc.relation.projectAndre: Austrian Science Fundnb_NO
dc.relation.projectAndre: Norwegian Directorate for Nature Managementnb_NO
dc.relation.projectAndre: Swedish Environmental Protection Agencynb_NO
dc.relation.projectAndre: Lundbeck Foundation (R126-2012-12408)nb_NO
dc.relation.projectNorges forskningsråd: xxxxxxnb_NO
dc.relation.projectAndre: Nordforsk researcher network grant (project no. 44042)nb_NO
cristin.unitnameNINA terrestrisk økologi

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal