Browsing NINA Brage by Author "Fröbert, Ole"

Now showing items 1-6 of 6

    • Cardiac adaptation in hibernating, free-ranging Scandinavian Brown Bears (Ursus arctos 

      Jørgensen, Peter Godsk; Evans, Alina; Kindberg, Jonas; Olsen, Lisbeth Høier; Galatius, Søren; Fröbert, Ole (Journal article; Peer reviewed, 2020)
      During six months of annual hibernation, the brown bear undergoes unique physiological changes to adapt to decreased metabolic rate. We compared cardiac structural and functional measures of hibernating and active bears ...

    • Elevated plasma phospholipid n-3 docosapentaenoic acid concentrations during hibernation 

      Strandvik, Birgitta; Qureshi, Abdul Rashid; Painer, Johanna; Backman-Johansson, Carolina; Engvall, Martin; Fröbert, Ole; Kindberg, Jonas; Stenvinkel, Peter; Giroud, Sylvain (Peer reviewed; Journal article, 2023)
      Factors for initiating hibernation are unknown, but the condition shares some metabolic similarities with consciousness/sleep, which has been associated with n-3 fatty acids in humans. We investigated plasma phospholipid ...

    • Hypothyroidism in hibernating brown bears 

      Frøbert, Anne Mette; Nielsen, Claus G.; Brohus, Malene; Kindberg, Jonas; Fröbert, Ole; Overgaard, Michael T. (Peer reviewed; Journal article, 2023)
      Brown bears hibernate throughout half of the year as a survival strategy to reduce energy consumption during prolonged periods with scarcity of food and water. Thyroid hormones are the major endocrine regulators of basal ...

    • Plasma proteomics data from hibernating and active Scandinavian brown bears 

      Fröbert, Anne Mette; Gregersen, Simon; Brohus, Malene; Welinder, Karen G.; Kindberg, Jonas; Fröbert, Ole; Overgaard, Michael T. (Peer reviewed; Journal article, 2022)
      In this article, we present mass-spectrometry based plasma proteomics data from hibernating and active free-ranging Scandinavian brown bears (Ursus arctos). The brown bear hibernates for half the year. Despite obesity when ...

    • Potential natural immunization against atherosclerosis in hibernating bears 

      Samal, Shailesh Kumar; Fröbert, Ole; Kindberg, Jonas; Stenvinkel, Peter; Frostegård, Johan (Peer reviewed; Journal article, 2021)
      Brown bears (Ursus arctos) hibernate for 5–6 months during winter, but despite kidney insufciency, dyslipidemia and inactivity they do not seem to develop atherosclerosis or cardiovascular disease (CVD). IgM antibodies ...

    • The Brown bear as a translational model for sedentary lifestyle-related diseases 

      Fröbert, Ole; Fröbert, Anne Mette; Kindberg, Jonas; Arnemo, Jon Martin; Overgaard, Michael Toft (Peer reviewed; Journal article, 2019)
      Sedentary lifestyle accelerates biological ageing, is a major risk factor for developing metabolic syndrome and is associated with cardiovascular disease, diabetes mellitus, kidney failure, sarcopenia and osteoporosis. ...